Novel Methods to Predict the Pharmacology and Effect of Anticancer Drugs

Grant number: 628564 | Funding period: 2010 - 2015

Completed

Abstract

Cancer patients have large differences in the way their liver breaks down anticancer drugs, leading to a poor tumor response or severe side effects. This project will be with 2 cancer drugs which can cause severe side effects. Patients will have special liver Xrays to check their liver function and have blood taken to look at DNA or genes important in drug breakdown and action. These genes and imaging may help identify patients at risk of severe toxicity or poor response and optimise drug use.

Related publications (3)

The utility of genomics and functional imaging to predict sunitinib pharmacokinetics and pharmacodynamics: The predict SU study

M Michael, GC Toner, V Ganju, E Link, M Thompson, A Matera, RJ Hicks, I Campbell, S Rowley, CS Karapetis, M Burge, DW Pook

2026-01-01

Aim: Sunitinib has marked pharmacokinetic (PK) and pharmacodynamic (PD) interpatient variability. This study evaluated the utility..

Evaluation of pharmacogenomics and hepatic nuclear imaging–related covariates by population pharmacokinetic models of irinotecan and its metabolites

Z Liu, JH Martin, W Liauw, SA McLachlan, E Link, A Matera, M Thompson, M Jefford, RJ Hicks, C Cullinane, A Hatzimihalis, I Campbell, S Crowley, PJ Beale, CS Karapetis, T Price, ME Burge, M Michael

2022-01-01

Background: Body surface area (BSA)–based dosing of irinotecan (IR) does not account for its pharmacokinetic (PK) and pharmacodyna..

Pharmacogenomics and functional imaging to predict irinotecan pharmacokinetics and pharmacodynamics: the predict IR study

M Michael, W Liauw, SA McLachlan, E Link, A Matera, M Thompson, M Jefford, RJ Hicks, C Cullinane, A Hatzimihalis, IG Campbell, S Rowley, PJ Beale, CS Karapetis, T Price, ME Burge

2021-07-01

Purpose: Irinotecan (IR) displays significant PK/PD variability. This study evaluated functional hepatic imaging (HNI) and extensi..

University of Melbourne Researchers

Michael Michael

Guy Toner